Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

作者：Koh Young Jun; Kim Hak Zoo; Hwang Seong Ik; Lee Jeung Eun; Oh Nuri; Jung Keehoon; Kim Minah; Kim Kyung Eun; Kim Homin; Lim Nam Kyu; Jeon Choon Ju; Lee Gyun Min; Jeon Byeong Hwa; Nam Do Hyun; Sung Hoon Ki; Nagy Andras; Yoo Ook Joon; Koh Gou Young^*

来源：Cancer Cell, 2010, 18(2): 171-184.

DOI：10.1016/j.ccr.2010.07.001

Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.

• 出版日期2010-8-17