A New Path to Leukemia with WIT

作者：Luis Sardina Jose; Graf Thomas

来源：Molecular Cell, 2015, 57(4): 573-574.

DOI：10.1016/j.molcel.2015.02.005

In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three genes inducing myeloid cell proliferation.

• 出版日期2015-2-19