Asymmetric bilateral effect of the supplementary motor area proper in the human motor system

作者：Kikuchi Takayuki; Matsumoto Riki; Mikuni Nobuhiro^*; Yokoyama Yohei; Matsumoto Atsuhito; Ikeda Akio; Fukuyama Hidenao; Miyamoto Susumu; Hashimoto Nobuo

来源：Clinical Neurophysiology, 2012, 123(2): 324-334.

DOI：10.1016/j.clinph.2011.06.011

• Human motor areas
• Functional connectivity
• Corticospinal tract
• Single-pulse electric stimulation
• Functional mapping

Objective: This study aimed to clarify the function of human supplementary motor area proper (SMA) by the single-pulse electric stimulation method and its clinical usefulness for SMA mapping. %26lt;br%26gt;Methods: We studied five patients with epilepsy or brain tumour who underwent invasive functional mapping with subdural electrodes. Single-pulse electric stimulation of primary motor area (MI) and SMA was carried out through pairs of subdural electrodes, and motor-evoked potentials (MEPs) were recorded from surface electromyogram on both sides and also cortico-cortical-evoked potentials (CCEPs) from electrocorticogram. %26lt;br%26gt;Results: SMA stimulation elicited: (1) MEPs and following silent periods (SPs) in the contralateral upper and lower extremities, (2) SPs with or without minimal MEPs in the ipsilateral upper extremity and (3) CCEPs in the somatotopically corresponding region of the ipsilateral MI. Compared with MI stimulation, SMA stimulation required higher stimulus intensities (mean 14.2 mA (SMA) vs. 8.5 mA (MI)) to elicit MEPs and showed significantly longer onset latencies in upper extremity (range: 4-10 ms). %26lt;br%26gt;Conclusions: The results demonstrated an asymmetric bilateral effect of human SMA upon the corticospinal pathway. %26lt;br%26gt;Significance: Single-pulse electric cortical stimulation would be clinically useful for distinguishing SMA from MI. The asymmetric bilateral effect of SMA might be conveyed through the direct descending pathway.

• 出版日期2012-2