Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

作者：Li, Ranwei; Liu, Tiecheng; Wang, Ke^*

来源：Biomedical Engineering-Biomedizinische Technik, 2017, 62(1): 67-73.

DOI：10.1515/bmt-2015-0238

• hyaluronic acid
• lung cancer
• paclitaxel
• zirco-nium phosphate

Novel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%+/- 4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity in vitro. In vivo anticancer efficacy assay revealed that HA-ZP nanoparticles possessed preferable anticancer abilities, which exhibited minimized toxic side effects of PTX and strong tumor-suppression potential in clinical application.

• 出版日期2017-2
• 单位吉林大学