Using synchrotron radiation angiography with a highly sensitive detector to identify impaired peripheral perfusion in rat pulmonary emphysema

作者：Ito Hiromichi; Matsushita Shonosuke^*; Hyodo Kazuyuki; Sato Yukio; Sakakibara Yuzuru

来源：Journal of Synchrotron Radiation, 2013, 20: 376-382.

DOI：10.1107/S090904951300040X

• pulmonary emphysema
• pulmonary microcirculation
• synchrotron radiation angiography
• sensitivity
• HARP detector

Owing to limitations in spatial resolution and sensitivity, it is difficult for conventional angiography to detect minute changes of perfusion in diffuse lung diseases, including pulmonary emphysema (PE). However, a high-gain avalanche rushing amorphous photoconductor (HARP) detector can give high sensitivity to synchrotron radiation (SR) angiography. SR angiography with a HARP detector provides high spatial resolution and sensitivity in addition to time resolution owing to its angiographic nature. The purpose of this study was to investigate whether this SR angiography with a HARP detector could evaluate altered microcirculation in PE. Two groups of rats were used: group PE and group C (control). Transvenous SR angiography with a HARP detector was performed and histopathological findings were compared. Peak density of contrast material in peripheral lung was lower in group PE than group C (p %26lt; 0.01). The slope of the linear regression line in scattering diagrams was also lower in group PE than C (p %26lt; 0.05). The correlation between the slope and extent of PE in histopathology showed significant negative correlation (p %26lt; 0.05, r = 0.61). SR angiography with a HARP detector made it possible to identify impaired microcirculation in PE by means of its high spatial resolution and sensitivity.

• 出版日期2013-3