A polymorphism in melanoma differentiation-associated gene 5 may be a risk factor for enterovirus 71 infection

作者：Pang L; Gong X; Liu N; Xie G; Gao W; Kong G; Li X; Zhang J; Jin Y; Duan Z^*

来源：Clinical Microbiology and Infection, 2014, 20(10): O711-O717.

DOI：10.1111/1469-0691.12618

• Enterovirus 71 infection
• MDA5
• RIG-I
• single-nucleotide polymorphism
• TLR3

Enterovirus 71 (EV71) infection has a wide variety of clinical manifestations, from no symptoms to fatal disease. Host immune response may be a determinant of disease severity. We investigated the association of polymorphisms in three pattern recognition receptor (PRR) genestoll-like receptor 3 (TLR3) (rs3775291), retinoic acid-inducible gene I (RIG-I) (rs10813831) and melanoma differentiation-associated gene 5 (MDA5) (rs1990760)with the severity of EV71 infection. Polymorphisms of candidate genes in 87 EV71-infected patients and 57 asymptomatic controls were detected. Binary logistic regression analysis revealed statistically significant differences in polymorphism of MDA5 (rs1990760) between patients with severe EV71 infection and asymptomatic controls in an additive model (OR 0.424, 95% CI 0.213-0.845, p0.015) and a dominant model (OR 0.256, 95% CI 0.103-0.635, p0.003). Polymorphism of MDA5 (rs1990760) (OR 0.399, 95% CI 0.199-0.798, p0.009) was found to be associated with the severity of EV71 infection with the analysis of ordinal logistic regression. These results indicated the association between MDA5 (rs1990760) polymorphism and an increased risk of a severe EV71 infection in Chinese children, which offers potential for investigating the innate immune mechanism of EV71 infection and identifying at-risk infants, for whom a preventive strategy may reduce the severity of EV71 infection.

• 出版日期2014-10
• 单位中国疾病预防控制中心病毒病预防控制所; 中国疾病预防控制中心; 中国中医科学院; 南京大学