Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality

作者：Botchkarev Vladimir A^*; Sharov Andrey A^*

来源：Journal of Investigative Dermatology, 2016, 136(3): 557-559.

DOI：10.1016/j.jid.2015.10.068

Chemotherapy-induced hair loss is one of the most devastating side effects of cancer treatment. To study the effects of chemotherapeutic agents on the hair follicle, a number of experimental models have been proposed. Yoon et al. report that transplantation of human scalp hair follicles onto chemotherapy-treated immunodeficient mice serves as an excellent in vivo model for chemotherapy-induced hair loss. Yoon et al. demonstrate that (i) the response of human hair follicles grafted onto immunodeficient mice to cyclophosphamide resembles the key features of the chemotherapy-induced hair loss seen in patients with cancer and (ii) this human in vivo model for chemotherapy-induced hair loss is closer to clinical reality than to any earlier models. Undoubtedly, this model will serve as a valuable tool for analyses of the mechanisms that underlie this devastating side effect of anti-cancer therapy.

• 出版日期2016-3