科研之友
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摘要
Introduction: Colorectal cancer is a common neoplasm in Europe and the United States. Even after apparently curative resection, recurrences occur in one-third of patients, usually within the first 2 to 3 years after the surgery. %26lt;br%26gt;Aim: Investigation the role of 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT) in detection of recurrent colorectal cancer. %26lt;br%26gt;Material and methods: A retrospective analysis of 75 tumours from 59 patients with recurrent colorectal carcinoma was made. %26lt;br%26gt;Results: Detecting recurrent colorectal cancer FDG PET/CT revealed 92% sensitivity. PET/CT correctly identified 69 of 75 tumours. Negative PET/CT results of the examination depend on necrotic changes occurring in them (p %26lt; 0.01). SUVmax in tumours without necrotic changes was indeed statistically higher than in tumours with necrotic changes (p %26lt; 0.01). SUVmax in tumours located in the liver is indeed statistically higher than in tumours located in lungs (p %26lt; 0.05). A correlation between SUVmax of the tumour and age of the patients and the maximum dimension of the tumour was not found (p %26lt; 0.05). %26lt;br%26gt;Conclusions: This study demonstrates that PET/CT is of high sensitivity. We conclude that FDG PET/CT is a powerful diagnostic imaging method, which has ability to improve accurate detection of recurrent colorectal cancer. The limitations of PET/CT are related to cellularity of the tumours. It is necessary to continue the study on correlation between SUV and molecular factors of tumours.
- 出版日期2012
