Antimicrobial and DNA-Cleavage Studies of 22-Membered N4 Tetraaza Macrocyclic Triazoles: Template Synthesis and Physicochemical Characterization

作者：Patil Sangamesh A^*; Kamble Udaykumar V; Badami Prema S

来源：Nucleosides Nucleotides & Nucleic Acids, 2010, 29(9): 658-675.

DOI：10.1080/15257770.2010.504600

• Synthesis
• complex
• macrocyclic
• bistriazole
• ortho-phthalaldehyde

A novel series of 22-membered macrocyclic complexes of the type [MLCl2] (M=Co2+, Ni2+ and Cu2+) have been synthesized with newly derived biologically active ligands (L1-LIV). These ligands were synthesized by the condensation of ortho-phthalaldehyde and bis-(4-amino-5-mercapto-1, 2, 4-triazole-3-yl)alkanes. The mode of bonding and overall geometry of the complexes have been inferred through IR, EPR, electronic spectral studies, conductivity, magnetic, thermal, and electrochemical studies. All these complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus, and Cladosporium) by the minimal inhibitory concentration (MIC) method. The DNA cleavage study was done by agarose gel electrophoresis technique.

• 出版日期2010