ARF: a versatile DNA damage response ally at the crossroads of development and tumorigenesis

作者：Kotsinas Athanassios; Papanagnou Panagiota; Evangelou Konstantinos; Trigas George C; Kostourou Vassiliki; Townsend Paul; Gorgoulis Vassilis G^*

来源：Frontiers in Genetics, 2014, 5: 236.

DOI：10.3389/fgene.2014.00236

Alternative reading frame (ARE) is a tumor suppressor protein that senses oncogenic and other stressogenic signals. It can trigger p53-dependent and -independent responses with cell cycle arrest and apoptosis induction being the most prominent ones. Other ARE activities, particularly p53-independent ones, that could help in understanding cancer development and provide potential therapeutic exploitation are underrated. Although ARE is generally not expressed in normal tissues, it is essential for ocular and male germ cells development. The underlying mechanism(s) in these processes, while not clearly defined, point toward a functional link between ARE DNA damage and angiogenesis. Based on a recent study from our group demonstrating a functional interplay between ataxia-telangiectasia mutated (ATM) and ARE during carcinogenesis, we discuss the role of ARE at the crossroads of cancer and developmental processes.

• 出版日期2014-7-22