Difference in expression of collagen type I and matrix metalloproteinase-1 in uterosacral ligaments of women with and without pelvic organ prolapse

作者：Vulic Marko^*; Strinic Tomislav; Tomic Snjezana; Capkun Vesna; Jakus Ivana Alujevic; Ivica Stipic

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2011, 155(2): 225-228.

DOI：10.1016/j.ejogrb.2010.12.019

• Collagen I
• Immunohistochemical expression
• Matrix metalloproteinase-1 (MMP-1)
• Pelvic organ prolapse
• Uterosacral ligament

Objective: To compare the expression of collagen type I and matrix metalloproteinase-1 (MMP-1) in uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP).
Study design: Uterosacral ligament biopsies were obtained from women with POP (n = 46) and control subjects (n = 49). Immunohistochemistry for collagen type I and MMP-1 was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. Statistical Package for the Social Sciences Version 13.0 was used for statistical analysis.
Results: The expression of collagen type I (p = 0.034) and MMP-1 (p 0.038) differed between women with POP and control subjects. There was increased expression of MMP-1 and decreased expression of collagen type 1 in uterosacral ligaments of women with POP compared with control subjects.
Conclusions: This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and MMP-1 in uterosacral ligaments.

• 出版日期2011-4