ANCA-associated Vasculitis with Central Retinal Artery Occlusion Developing during Treatment with Methimazole

作者：Yasude Takuji; Kishida Dai; Tazawa Ko ichi; Matsuda Masayuki^*; Ishii Wataru; Yazaki Masahide; Ikeda Shu ichi

来源：Internal Medicine, 2012, 51(22): 3177-3180.

DOI：10.2169/internalmedicine.51.8486

• ANCA-associated vasculitis
• central retinal artery occlusion
• methimazole
• MPO-ANCA

A 63-year-old woman suddenly developed central retinal artery occlusion following a slight fever while being treated with methimazole (MMI) for hyperthyroidism. She was diagnosed to have anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on increased inflammatory reactions with positive myeloperoxidase-ANCA in the serum. Her visual acuity remained low despite immediate treatment with corticosteroids and cyclophosphamide after cessation of MMI, which may have played a role in the pathogenesis of AAV. Central retinal artery occlusion is a rare manifestation of AAV; however, it is important with regard to the possibility of serious sequelae.

• 出版日期2012