Nickel-catalyzed reductive arylation of activated alkynes with aryl iodides

作者：Dorn Stephanie C M; Olsen Andrew K; Kelemen Rachel E; Shrestha Ruja; Weix Daniel J^*

来源：Tetrahedron Letters, 2015, 56(23): 3365-3367.

DOI：10.1016/j.tetlet.2015.02.120

• Reductive
• Arylation
• Alkyne
• Nickel
• Catalyzed

The direct, regioselective, and stereoselective arylation of activated alkynes with aryl iodides using a nickel catalyst and manganese reductant is described. The reaction conditions are mild (40 degrees C in MeOH, no acid or base) and an intermediate organomanganese reagent is unlikely. Functional groups tolerated include halides and pseudohalides, free and protected anilines, and a benzyl alcohol. Other activated alkynes including an amide and a ketone also reacted to form arylated products in good yields.

• 出版日期2015-6-3