Antioxidant flavanes from Livistona chinensis

作者：Zeng, Xiaobin; Qiu, Qian; Jiang, Chenguang; Jing, Yuntiao; Qiu, Guofu; He, Xiangjiu^*

来源：Fitoterapia, 2011, 82(4): 609-614.

DOI：10.1016/j.fitote.2011.01.017

• Livistona chinensis
• Flavanes
• Antiproliferative activity
• Antioxidant activity

Three new flavanes and eight known flavonoids were isolated from the fruits of Livistona chinensis. The structure of the new flavanes were established as 2S,3S-3,5,7,3',5'-pentahydroxyflavane (1), 2R,3R-3,5,6,7,8,4'-hexahydroxyflavane (2) and 2R,3R-3,5,6,7,8,3',5'-heptahydroxyflavane (3), respectively, on the basis of chemical and spectroscopic data. The antiproliferative activity against four human tumor cell lines (HL-60, Mata, HepG2 and CNE-1) was evaluated. 1 had significantly antiproliferative effects against HL-60 and CNE-1 with the IC50 of 0.2 +/- 0.01 and 1.0 +/- 0.1 mu M, respectively, overpowering the reference compound in the assay (cisplatin). Most compounds also exhibited potent antioxidant activity.

• 出版日期2011-6
• 单位武汉大学