Anti-Carbonic Anhydrase II Antibodies in End-Stage Renal Disease Patients

作者：Alver Ahmet^*; Mentese Ahmet; Mentese Umit; Sumer Aysegul; Ucar Fahri; Altay Diler Us

来源：Medical Principles and Practice, 2014, 23(4): 331-335.

DOI：10.1159/000362667

• End-stage renal disease
• Carbonic anhydrase II
• Malondialdehyde
• Autoimmunity
• Ghrelin

Objective: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine. Subjects and Methods: Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. Results: The CA II autoantibody titers in the ESRD group (0.170 +/- 0.237) were significantly higher than those in the control group (0.079 +/- 0.032; p = 0.035). MDA and ghrelin levels were also significantly higher in the ESRD group (p < 0.001). A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers (r = 0.287, p = 0.028 and r = -0.278, p = 0.032, respectively). Conclusions: In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti-CA II antibodies could be involved in the pathogenesis of ESRD.

• 出版日期2014