Antimicrobial Metabolites from Streptomyces sp SN0280

作者：Tian, Hui; Shafi, Jamil; Ji, Mingshan; Bi, Yuhui; Yu, Zhiguo^*

来源：Journal of Natural Products, 2017, 80(4): 1015-1019.

DOI：10.1021/acs.jnatprod.6b01016

• ANTIFUNGAL ACTIVITY
• NATURAL-PRODUCTS
• PLANT-PATHOGENS
• ANTIBIOTICS
• DISCOVERY
• AGENTS

One new indole derivative, chloroindole (1), one new diketone, streptoone A (2), two new ketonic acids, streptoones B (3) and C (4), and one known macrolide antibiotic, X-14952B (5), were isolated from Streptomyces sp. SN0280. Extensive NMR, HRESIMS, and IR analysis was used to elucidate their structures. Streptoone A (2) displayed antibacterial activity (MIC value of 7.81 yg/mL) against Clavibater michiganensis, comparable with the positive control streptomycin (MIC value of 7.81 mu g/mL). Streptoone B (3)' showed antifungal activity (MIC value of 15.63 mu g/mL) against Phytophthora capsici (positive control carbendazol MIC value of 7.81 mu g/mL). These molecules provide new templates for the phytopathogens.

• 出版日期2017-4
• 单位沈阳农业大学