A new spirocyclic compound from the liquid culture of entomogenous fungus Isaria cateniannulata

作者:Yang Xiao Long*; Li Zhuang Zhuang; Zhang Su; Yu He; Zhu Hua Jie; Luo Du Qiang
来源:Journal of Asian Natural Products Research, 2012, 14(11): 1093-1096.
DOI:10.1080/10286020.2012.707650

摘要

A new spirocyclic compound named (2S, 5S, 7S)-3a-hydroxyl-exogonic acid (1) was isolated from the liquid culture of entomogenous fungus Isaria cateniannulata. The structure and relative stereochemistry of 1 were elucidated by extensive spectroscopic analysis and by comparison of its NMR data with those of known compound. Compound 1 showed weak inhibitory activity against HeLa with IC50 value of 80.5 mu g ml- 1.

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