A photo-controlled hyaluronan-based drug delivery nanosystem for cancer therapy

作者：Sun, Feifei; Zhang, Peng; Liu, Yinyin; Lu, Chunbo; Qiu, Yuanhao; Mu, Haibo; Duan, Jinyou^*

来源：Carbohydrate Polymers, 2019, 206: 309-318.

DOI：10.1016/j.carbpol.2018.11.005

• Hyaluronan
• Nanomicelles
• Photo-controlled
• Targeted delivery

In this paper, a novel photo-controlled drug-loaded nanomicelles were self-assembled by the amphiphile of hyaluronan-o-nitrobenzyl-stearyl chain (HA-NB-SC) with doxorubicin (DOX) encapsulated within the hydrophobic core. DOX-loaded HA-NB-SC nanomicelles are similar to 139 nm in diameter. CD44-overexpressed HeLa cells can easily take up HA-NB-SC micelles through recognition of HA moiety. DOX-loaded HA-NB-SC nanomicelles could be disassembled upon UV light (365 nm) and consequently, release DOX at desired pathological sites. Furtherly, nitrosobenzaldehyde derivative, photo-induced products of HA-NB-SC and DOX could inhibit the proliferation of HeLa cells together. This strategy may shed some light on delivery of hydrophobic anti-cancer drugs in a controlled manner.

• 出版日期2019-2-15
• 单位西北农林科技大学