AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

作者：Esseltine Jessica L; Scott John D^*

来源：Trends in Pharmacological Sciences, 2013, 34(12): 648-655.

DOI：10.1016/j.tips.2013.10.005

• AKAP
• protein kinase
• protein phosphatase
• Ca2+
• signal transduction
• disease
• interfering peptide

A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling enzymes with their substrates. Great strides have been made in elucidating the role of these macromolecular signaling complexes as new binding partners and novel AKAPs are continually being uncovered. The mechanics and dynamics of these multi-enzyme-assemblies suggest that AKAP complexes are viable targets for therapeutic intervention. This review will highlight recent advances in AKAP research focusing on local signaling events that are perturbed in disease.

• 出版日期2013-12