Dermal Scatter Reduction in Human Skin: A Method Using Controlled Application of Glycerol

作者：Fox Matthew A; Diven Dayna G; Sra Karen; Boretsky Adam; Poonawalla Tasneem; Readinger Allison; Motamedi Massoud; McNichols Roger J^*

来源：Lasers in Surgery and Medicine, 2009, 41(4): 251-255.

DOI：10.1002/lsm.20767

• dermal scatter reduction
• glycerol
• optical clearing
• skin
• transdermal
• tattoo removal

Background and Objective: Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study Focuses on the application of this protocol on human patients.
Study Design/Materials and Methods: After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.
Results/Conclusion: Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light-based diagnostic or therapeutic devices. Lasers Surg. Med.41:251-255,2009.

• 出版日期2009-4