Annual Incidence of Lassa Virus Infection in Southern Mali

作者：Safronetz David; Sogoba Nafomon; Diawara Sory Ibrahim; Bane Sidy; Rosenke Kyle; Maiga Ousmane; Boisen Matt; Garry Robert F; Branco Luis M; Lindsay L Robbin; Traore Sekou F; Feldmann Heinz^*; Doumbia Seydou

来源：The American Journal of Tropical Medicine and Hygiene, 2017, 96(4): 944-946.

DOI：10.4269/ajtmh.16-0821

Previously, we reported a high seroprevalence rate of Lassa virus antibodies in inhabitants of three villages in southern Mali where infected rodents have been demonstrated. Herein, we report a 1-year follow-up study in which we were able to collect a second blood samples from 88.7% of participants of the same cohort. We identified 23 seroconversions for IgG antibodies reactive against Lassa virus, representing an incidence of 6.3% (95% confidence interval = 3.8-8.8%). Seroconversion was frequently seen in preteenage children (12/23, 51.7%) and two household/familial clusters were identified. These results confirm active transmission of Lassa virus is occurring in southern Mali and appropriate diagnostic testing should be established for this etiological agent of severe viral hemorrhagic fever.

• 出版日期2017
• 单位NIH