A highly enantioselective access to chiral chromanones and thiochromanones via copper-catalyzed asymmetric conjugated reduction of chromones and thiochromones

作者：Xiong, Donglu; Zhou, Wenxi; Lu, Zhiwu; Zeng, Suping; Wang, Jun^*

来源：Chemical communications, 2017, 53(51): 6844-6847.

DOI：10.1039/c7cc03939e

The chromanone scaffold is a privileged structure in heterocyclic chemistry and drug discovery. A highly efficient copper-catalyzed asymmetric conjugated reduction of chromones is developed to give chiral chromanones with good yields ( 80-99%) and excellent ee values ( 94- > 99% ee). Particularly noteworthy is that chiral thiochromanones are also constructed using this method in 74-87% yields with 96-97% ee. The established asymmetric synthesis paves the way for their further pharmaceutical studies.

• 出版日期2017-6-28
• 单位南方科技大学