Absent or Extremely Low Neutrophil Alkaline Phosphatase Activity Levels in Patients with Myelodysplastic Syndromes

作者：Yoshida Yataro^*; Katsurada Tatsuya; Oguma Shigeru; Nakabo Yukiharu; Yoshinaga Noriyoshi; Kawahara Masahiro; Kawabata Hiroshi

来源：Internal Medicine, 2013, 52(4): 479-482.

DOI：10.2169/internalmedicine.52.9114

• neutrophil alkaline phosphatase
• myelodysplasia

Three patients with myelodysplastic syndrome (MDS) had absent or extremely low levels of neutrophil alkaline phosphatase (NAP) activity (arbitrarily defined as an NAP score <10). All patients showed varying degrees of hypogranulation in neutrophil morphology. The NAP activity levels transiently normalized following the administration of granulocyte colony-stimulating factor (G-CSF) in two cases. No patients experienced any severe infectious episodes. These results suggest that NAP activity is not central to the neutrophil function.

• 出版日期2013