Aporphine Alkaloids from Illigera aromatica from Guangxi Province, China

作者：Ge, Yi-Chao; Zhang, Hai-Jiang; Wang, Kui-Wu^*; Fan, Xin-Feng

来源：Phytochemistry, 2018, 154: 73-76.

DOI：10.1016/j.phytochem.2018.06.017

• Illigera aromatica
• Hernandiaceae
• Aporphine alkaloid
• NMR
• Cytotoxicity

Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (H-1, C-13, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC50 values of 32.42-62.90 mu M. Only compound 1 had in vitro cytotoxic activity against Bcap37 cells, with the IC50 value of 90.61 mu M.

• 出版日期2018-10
• 单位浙江工商大学; 淮阴工学院