Molecular imprinting in monolayer surfaces

作者：Balamurugan Subramanian; Spivak David A^*

来源：Journal of Molecular Recognition, 2011, 24(6): 915-929.

DOI：10.1002/jmr.1150

• molecular imprinting
• self-assembled monolayers
• surface imprinting
• molecular recognition

A comprehensive report on molecularly imprinted monolayers (MIMs) is presented, but does not include bulk-polymer thin film coatings on surfaces, inorganic surface imprinting, polymer grafting and layer-by-layer methods. Due to difficulties in imprinting large molecules and obtaining fast binding responses with traditional network polymer materials, MIMs have been developed with the aim of enhancing mass-transfer of analytes in imprinted materials. Three approaches to MIM fabrication have been developed with respect to the formation of the pre-organized template-matrix complex. In the first approach, the molecular binding sites are formed in a monolayer on a glass or gold surface. The second approach uses a template-macromolecule complex to form binding sites in the solution phase that are immobilized onto a surface; and the third approach transfers an imprinted Langmuir film onto a gold surface. Mass transfer in these MIMs inmost cases is on the order of minutes, and both small and large molecules (proteins) have been imprinted.

• 出版日期2011-12