Brain lipidomic changes after morphine, cocaine and amphetamine administration - DESI - MS imaging study

作者：Bodzon Kulakowska Anna; Antolak Anna; Drabik Anna; Marszalek Grabska Marta; Kotlinska Jolanta; Suder Piotr^*

来源：Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 2017, 1862(7): 686-691.

DOI：10.1016/j.bbalip.2017.04.003

• Drug addiction
• Lipidomics
• Mass spectrometry imaging
• Desorption electrospray

Drug addiction is a complex disorder, evoking significant changes in the proteome of the central nervous system. To check if there are also changes in the lipidomic profiles we used desorption electrospray-MS technique for imaging of the brain slices of rats exposed to morphine, cocaine and amphetamine. Our investigations showed alternative regulation of selected lipid's levels in the central nervous system structures, under the influence of applied drugs. Results of our investigations can show changes in the brain treated with drugs of abuse in the new light, indicating role of the lipids in the addiction development.

• 出版日期2017-7