Aspirin prevents diabetic oxidative changes in rat lacrimal gland structure and function

作者：Jorge Angelica Gobbi; Modulo Carolina Maria; Dias Ana Carolina; Braz Alexandre Martins; Bertazolli Filho Rubens; Jordao Alceu A Jr; de Paula Jayter Silva; Rocha Eduardo Melani^*

来源：Endocrine, 2009, 35(2): 189-197.

DOI：10.1007/s12020-009-9151-9

• Anti inflammatory drugs
• Anti-oxidant capacity
• Lacrimal gland
• Uncoupled protein
• Diabetes mellitus
• Oxidative stress

The aim of this study is to evaluate whether aspirin reduces Diabetis Mellitus (DM) oxidative damage in the lacrimal gland (LG), and ocular surface (OS). Ten weeks after streptozotocin induced DM and aspirin treatment, LG and OS of rats were compared for tear secretion, hidtology, peroxidase activity, and expression of uncoupling proteins (UCPs). DM reduction of tear secretion was prevented by aspirin (P < 0.01). Alterations of LG morphology and increased numbers of lipofucsin-like inclusions were observed in diabetic but not in aspirin-treated diabetic rats. Peroxidase activity levels were higher and UCP-2 was reduced in DM LG but not in aspirin treated (P = 0.0025 and P < 0.05, respectively). The findings prevented by aspirin indicate a direct inhibitory effect on oxidative pathways in LG and their inflammatory consequences, preserving the LG structure and function against hyperglycemia and/or insulin deficiency damage.

• 出版日期2009-4