科研之友
微信
新浪微博
Facebook
分享链接
摘要
The association of the phospholipase A2 group VI gene (PLA2G6) single nucleotide variants (SNVs) and exposure factors with lipid-related traits is little known. This study sought to determine the interactions of the PLA2G6 rs4820314 SNV and several exposure factors on lipid-associated phenotypes in the Chinese Jing and Han populations. A total of 1629 unrelated participants (Jing, 785 and Han, 844) were randomly selected from our previous stratified randomized samples. Genotypes of the PLA2G6 rs4820314 were determined by polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing. Analyses were performed to assess the interaction between genotypes and several exposure factors on serum lipid levels. The levels of serum total cholesterol and triglyceride (TG) were higher in Jing than in Han. The genotypic and allelic frequencies of PLA2G6 rs4820314 were different between the two populations and body mass index (BMI), alcohol consumption and hyperlipidemia subgroups (P < 0.05-0.001). The A allele carriers had higher serum TG levels and the risk of hyperlipidemia than the A allele non-carriers. Consistently, in each population, serum TG levels increased more evidently with higher BMI and/or alcohol consumption of PLA2G6 rs4820314 AG/AA genotype than in carriers of the major genotype (GG). Participants with different genotypes of PLA2G6 rs4820314 exhibit differential effected from BMI and alcohol consumption for the hyperlipidemia risk. These findings suggest potential critical roles for the gene-exposure (GxE) interaction between PLA2G6 rs4820314 and BMI/alcohol consumption in regulating lipid-related traits and hypertriglyceridemia risk.
- 出版日期2017
- 单位广西医科大学
