Antiinflammatory and Analgesic Activities of Different Fractions of Populus tomentosa Carr. Leaves

作者：Fu, Xueyan^*; Li, Tingting; Zhang, Baitong; Zhang, Xinhui; Dong, Lin; Ma, Xueqin; Chen, Jing; Qin, Luping

来源：Asian Journal of Chemistry, 2014, 26(15): 4643-4647.

DOI：10.14233/ajchem.2014.16152

• Populus tomentosa leaves
• Screening
• Active fraction
• Antiinflammatory
• Analgesic

The antiinflammatory and analgesic properties of different polar fractions of Populus tomentosa leaves were investigated in mice. The analgesic activities of leaf extracts were evaluated with hot-plate and acetic acid writhing tests. Anti-inflammatory effects were studied using xylene-induced ear edema and egg albumen-induced paw edema. Low dose (1 g/kg) and high dose (3 g/kg) aqueous extracts had significant analgesic effects (p < 0.05) for the acetic acid writhing test. High doses of ethanol (3 g/kg), petroleum ether (0.5 g/kg) and butanol extracts (0.5 g/kg) prolonged hot-plate reaction times (p < 0.05) and had better analgesia. Petroleum ether extract (0.5 g/kg) was better than controls for reducing xylene-induced ear edema (p < 0.05). Low doses of aqueous (1 g/kg), ethyl acetate (0.5 g/kg) and butanol extracts (0.5 g/kg) reduced foot swelling due to egg albumen better than controls (p < 0.05). These findings indicate that water and ethanol extracts, as well as different ethanol polarity fractions, from Populus tomentosa leaves have analgesic and anti-inflammatory effects which are consistent with their use in traditional medicine.

• 出版日期2014-8
• 单位宁夏医科大学