Ante mortem amyloid imaging and beta-amyloid pathology in a case with dementia with Lewy bodies

作者：Kantarci Kejal^*; Yang Chunhui; Schneider Julie A; Senjem Matthew L; Reyes Denise A; Lowe Val J; Barnes Lisa L; Aggarwal Neelum T; Bennett David A; Smith Glenn E; Petersen Ronald C; Jack Clifford R Jr; Boeve Bradley F

来源：Neurobiology of Aging, 2012, 33(5): 878-885.

DOI：10.1016/j.neurobiolaging.2010.08.007

• Dementia with Lewy bodies
• Amyloid imaging
• PET
• Pathology
• Amyloid

The association between ante mortem [C-11]-Pittsburgh Compound B (PiB) retention and beta-amyloid (A beta) load, Lewy body (LB) and neurofibrillary tangle (NFT) densities were investigated in a pathologically confirmed case of dementia with Lewy bodies (DLB). A 76 year old man presenting with a clinical diagnosis of DLB had undergone PiB-positron emission tomography (PET), F-18 FDG-PET and magnetic resonance imaging (MRI) 18 months before death. The pathologic diagnosis was DLB neocortical-type with low-likelihood of Alzheimer%26apos;s disease by NIA-Reagan criteria. Sections from regions of interest (ROI) on post-mortem examination were studied. A significant correlation was found between cortical A beta density and PiB retention in the 17 corresponding ROIs (r = 0.899; p %26lt; 0.0001). Bielschowsky silver stain revealed mostly sparse neocortical neuritic plaques, whereas diffuse plaques were frequent. There was no correlation between LB density and PiB retention (r = 0.13; p = 0.66); nor between NFT density and PiB retention (r = -0.36; p = 0.17). The ROI-based analysis of imaging and histopathological data confirms that PiB uptake on PET is a specific marker for A beta density, but cannot differentiate neuritic from diffuse amyloid plaques in this case with DLB.

• 出版日期2012-5