Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines

作者：Toe Jesse G; Pellegrini Marc^*; Mak Tak Wah

来源：Molecular Immunology, 2013, 55(1-2): 38-47.

DOI：10.1016/j.molimm.2013.04.008

• Common gamma-chain
• Cytokines
• HIV
• Infection
• CD8(+) T cell
• Therapy

The continued global burden wrought by chronic infectious disease is unrelenting. Current therapies have curbed the severity of disease for patients, but Human Immunodeficiency Virus (HIV) and Hepatitis B (HBV) infection remain incurable and Mycobacterium tuberculosis (MTB) is rapidly becoming resistant to our existing antibiotics. Much attention has been given to enhancing T cell immunity through the use of certain common gamma-chain cytokines, which have proven to be essential and necessary for T cell survival and function. This article reviews the pre-clinical and clinical literature surrounding IL-2, IL-7, IL-15 and IL-21 and we comment on the potential therapeutic promise of these cytokines as adjuvant treatments for chronic infectious diseases.

• 出版日期2013-11
• 单位河北医科大学