A novel beta-catenin signaling pathway activated by IL-1 beta leads to the onset of epithelial-mesenchymal transition in breast cancer cells

作者：Andres Perez Yepez Eloy; Ayala Sumuano Jorge Tonatiuh; Lezama Ruth; Meza Isaura^*

来源：Cancer Letters, 2014, 354(1): 164-171.

DOI：10.1016/j.canlet.2014.08.015

• Breast cancer cell
• IL-1 beta stimulation
• IL-1RI/beta-catenin signaling
• Invasiveness

Interieukin 1 beta has been associated with tumor development, invasiveness and metastasis in various types of cancer. However, the molecular mechanisms underlying this association have not been clearly elucidated. The present study is the first to show, in breast cancer cells, that an IL-1 beta/IL-1RI/beta-catenin signaling pathway induces beta-catenin accumulation due to GSK3 beta inactivation by Ala phosphorylation. Translocation to the nucleus of accumulated beta-catenin and formation of the TCF/Lef/beta-catenin complex induce sequential expression of c-MYC, CCDN1, SNAIL1 and MMP2, leading to up-regulation of proliferation, migration and invasion; all of the processes shown to be required, in cancerous cells, to initiate transition from a non-invading to an invasive phenotype.