A simple two-step access to diversely substituted imidazo[4,5-b]pyridines and benzimidazoles from readily available 2-imidazolines

作者：Mujumdar Prashant; Grkovic Tanja; Krasavin Mikhail^*

来源：Tetrahedron Letters, 2013, 54(26): 3336-3340.

DOI：10.1016/j.tetlet.2013.04.036

• Pd-catalyzed arylation
• N-(Hetero)aryl 2-imidazolines
• Bechamp reduction
• Rearrangement Imidazo[4,5-b]pyridines
• Benzimidazoles

We discovered a facile rearrangement of N-(hetero)aryl 2-imidazolines into diversely substituted imidazo[4,5-b]pyridines and benzimidazoles, under Bechamp reduction conditions. Combined with the earlier reported protocol for Pd-catalyzed (hetero)arylation of 2-imidazolines, it provides a simple two-step access to a range of compounds based on these medicinally important heterocyclic cores.

• 出版日期2013-6-26