Non-invasive measurement of cardiac output by Finometer in patients with cirrhosis

作者：Kaltoft N; Hobolth L; Moller S^*

来源：Clinical Physiology and Functional Imaging, 2010, 30(4): 230-233.

DOI：10.1111/j.1475-097X.2010.00932.x

• cardiac output
• cardiovascular diagnostic techniques
• cardiovascular model
• Finapres
• ModelFlow

P>The Finometer measures haemodynamic parameters including cardiac output (CO) using non-invasive volume-clamp techniques. The aim of this study was to determine the accuracy of the Finometer in hyperdynamic cirrhotic patients using an invasive indicator dilution technique as control. CO was measured in twenty-three patients referred for invasive measurements of the hepatic venous pressure gradient on suspicion of cirrhosis. Invasive measurements of CO were performed using indicator dilution technique (CO(I)) and simultaneous measurements of CO were recorded with the Finometer (CO(F)). In six patients, measurements of CO were performed with invasive technique and the Finometer both before and after beta-blockade using 80 mg of propranolol and the changes in CO (Delta CO(I) and Delta CO(F) respectively) were calculated to evaluate the Finometers ability to detect relative changes in CO. Mean CO(I) was 6 center dot 1 +/- 1 center dot 6 [3 center dot 9;9 center dot 7] l min-1 (mean +/- SD [range]) compared to mean CO(F) of 7 center dot 2 +/- 2 center dot 3 [3 center dot 1;11 center dot 9] l min-1. There was a mean difference between CO(F) and CO(I) of 1 center dot 0 +/- 1 center dot 8 [-2 center dot 1;4 center dot 0] l min-1 and 95% confidence interval of [0 center dot 2;1 center dot 8], P < 0 center dot 001. In patients with measurements before and after beta-blockade, mean Delta CO(I) was 1 center dot 6 +/- 1 center dot 4 [-0 center dot 1;3 center dot 3] l min-1 compared to mean Delta CO(F) of 1 center dot 9 +/- 1 center dot 3 [0 center dot 4;3 center dot 8] l min-1. Mean difference between Delta CO(F) and Delta CO(I) was 0 center dot 3 +/- 0 center dot 3 [-0 center dot 2;0 center dot 7] l min-1 with a 95% confidence interval of [-0 center dot 1;0 center dot 6], P = 0 center dot 11. Compared with invasive measurements, the Finometer can be used to measure changes in CO, whereas absolute measurements are associated with higher variation in patients with cirrhosis. The Finometer seems useful for repeated determinations such as in studies of effect of pharmacotherapy.

• 出版日期2010-7