Advances in mechanisms of allergic disease in 2016

作者：Rothenberg Marc E^*; Saito Hirohisa; Peebles R Stokes Jr

来源：Journal of Allergy and Clinical Immunology, 2017, 140(6): 1622-1631.

DOI：10.1016/j.jaci.2017.08.029

• Allergy
• immunology
• innate
• inflammation
• food allergy
• asthma
• mast cell
• eosinophil
• ozone
• IL-33
• extracellular vesicles

This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; T(H)2 lymphocytes; eicosanoid regulation of inflammation; extracellular vesicles in allergic responses; IL-33; microbiome properties, especially as they relate to mucosal barrier function; and a series of findings concerning the allergic inflammatory cells eosinophils, basophils, and mast cells. During the last year, mechanistic advances occurred in understanding type 2 innate lymphoid cells, particularly related to their response to ozone, involvement with experimental food allergy responses, and regulation by IL-33. Novel ways of regulating T(H)2 cells through epigenetic regulation of GATA-3 through sirtuin-1, a class III histone deacetylase, were published. The understanding of eicosanoid regulation of inflammation increased and focused on additional properties of phospholipase A(2) and the role of prostaglandin D-2 and its receptors and inhibitory prostaglandin E-2 pathways. Mechanisms through which extracellular vesicles are released and contribute to allergic responses were reported. There was a deeper appreciation of mucosal barrier function, the epithelial alarmin IL-33, and the microbiome. Finally, there were advances concerning allergic inflammatory cells (mast cells, basophils, and eosinophils) that will undoubtedly have an effect on disease understanding and new therapeutic strategies.

• 出版日期2017-12