Phytochemicals in the Treatment of Alzheimer's Disease: A Systematic Review

作者：D'Onofrio Grazia^*; Sancarlo Daniele; Ruan Qingwei; Yu Zhuowei; Panza Francesco; Daniele Antonio; Greco Antonio; Seripa Davide

来源：Current Drug Targets, 2017, 18(13): 1487-1498.

DOI：10.2174/1389450117666161102121553

• Phytochemicals
• Alzheimer's disease
• antioxidant properties
• anti-inflammatory activities
• acetilcholinesterase inhibitors
• AChEIs

Background: Alzheimer's disease (AD) is the most widespread age-related neurodegenerative disease. Recently, a growing body of evidence suggested the phytochemical use to slow down AD onset and progression.
Objective: To review the phytochemical role potentially involved in AD treatment.
Method: A systematic review from existing literature on phytochemicals used in the treatment of AD patients was conducted. Selection criteria included: 1) age >= 60 years; 2) AD diagnosis in agreement with the criteria of National Institute on Aging-Alzheimer's Association (NIAAA), and 3) suitable measures to asses cognitive, functional and clinical status.
Results: Ninety-seven articles were involved in the present study. Several phytochemicals seem to slow down AD onset, delay disease progression and let recovery through targeting multiple pathological causes by anti-cholinergic, antioxidant and anti-inflammatory features.
Conclusion: Deeper knowledge on phytochemicals and their specific molecular targets is essential to guarantee safe use of these compounds as an option for AD treatment.

• 出版日期2017
• 单位复旦大学