Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes

作者：Perez Galan Patricia; Waldmann Herbert; Kumar Kamal

来源：Tetrahedron, 2016, 72(26): 3647-3652.

DOI：10.1016/j.tet.2016.03.020

• Indole polycycles
• Gold catalysis
• Cycloisomerization
• Enynes
• Cycloadditions

A gold(I) catalyzed cycloisomerization of indolyl-1,6-enynes via 5-exo-dig cyclization is reported. The reaction passes through an intermediate whose fate can be steered to yield different indole polycyclic scaffolds through various intra-and inter-molecular cyclization reactions. One of the key transformations of indolyl-1,6-enynes was a formal [2+2+2] cycloaddition reaction with various aldehydes to afford natural product-like tetracyclic indoles.

• 出版日期2016-6-30