Applicability of hybrid linear ion trap-high resolution mass spectrometry and quadrupole-linear ion trap-mass spectrometry for mycotoxin analysis in baby food

作者：Rubert Josep^*; James Kevin J; Manes Jordi; Soler Carla

来源：Journal of Chromatography A, 2012, 1223: 84-92.

DOI：10.1016/j.chroma.2011.12.039

• Orbitrap
• QTRAP
• MSPD
• Mycotoxins
• Baby food

Recent developments in mass spectrometers have created a paradoxical situation; different mass spectrometers are available, each of them with their specific strengths and drawbacks. Hybrid instruments try to unify several advantages in one instrument. In this study two of wide-used hybrid instruments were compared: hybrid quadrupole-linear ion trap-mass spectrometry (QTRAP (R)) and the hybrid linear ion trap-high resolution mass spectrometry (LTQ-Orbitrap (R)). Both instruments were applied to detect the presence of 18 selected mycotoxins in baby food. Analytical parameters were validated according to 2002/657/CE. Limits of quantification (LOQs) obtained by QTRAP (R) instrument ranged from 0.45 to 45 mu g kg(-1) while lower limits of quantification (LLOQs) values were obtained by LTQ-Orbitrap (R): 7-70 mu g kg(-1). The correlation coefficients (r) in both cases were upper than 0.989. These values high-lighted that both instruments were complementary for the analysis of mycotoxin in baby food; while QTRAP (R) reached best sensitivity and selectivity, LTQ-Orbitrap (R) allowed the identification of non-target and unknowns compounds.

• 出版日期2012-2-3