Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase

作者：Arai Noriyoshi; Onodera Nozomi; Dekita Atsushi; Hori Junichi; Ohkuma Takeshi^*

来源：Tetrahedron Letters, 2015, 56(25): 3913-3915.

DOI：10.1016/j.tetlet.2015.04.116

• Palladium
• Nanoparticles
• Hydrogenation
• Nitroarenes
• Chemoselective

Palladium nanoparticles stabilized by alkyne derivatives catalyzed the hydrogenation of nitroarenes to the aryl amines in homogeneous phase. The reaction of nitrobenzene proceeded smoothly with a substrate-to-palladium molar ratio (S/Pd) of 51,000 under 8 atm of H-2. The reaction under 1 atm of H-2 with an S/Pd of 1030 was completed in 4 h. A series of substituted nitroarenes, including 4-acetyl- and 4-formylnitrobenzenes, were converted to the aryl amines with high chemoselectivity.

• 出版日期2015-6-17