New Secondary Metabolites from an Endophytic Fungus in Porodaedalea pini

作者：Yang Shuen Shin; Cheng Ming Jen^*; Chan Hing Yuen; Hsieh Sung Yuan; Wu Ho Cheng; Yuan Gwo Fang; Lin Chu Hung; Chang Hsun Shuo^*; Chen Ih Sheng^*

来源：Records of Natural Products, 2017, 11(3): 251-257.

• Porodaedalea pini
• fungus
• benzenoids
• NO inhibitory activity
• androgen antagonism

Eight benzenoids including three new phenols, piniphenols A-C (1-3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl) ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 mu M. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 mu M. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.

• 出版日期2017-6