Analysis of early predictor effect of serum Glutathione S-Transferase P1 isoenzyme on post-operative results in paediatric cardiac surgery

作者：Gocen Ugur^*; Keklik Vecih; Atalay Atakan; Yaliniz Hafize; Salih Orhan Kemal

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(6): 11494-11501.

• Paediatric open cardiac surgery
• cardiopulmonary bypass
• Glutathione S-Transferase P1 isoenzyme
• creatinine
• prognosis

Backround: Glutathione S-Transferase P1 is an important enzyme playing role in detoxification of oxidative stress products developing in the course of inflammation. Aim: The aim of this study was to detect if Glutathione S-Transferase P1 (GSTP1) isoenzyme might be an early predictor of mortality. Methods: This prospective study examined 30 paediatric patients to have had open cardiac surgery under cardiopulmonary bypass. Patients were divided into two groups; those discharged without any problem (Group 1, N=23) and exitus (Group 2, N=7). Blood samples were collected at five times of (i) after anesthesia induction (T1), (ii) 10 minutes after cardiopulmonary bypass started (T2), (iii) 10 minutes after cross clamp was placed (T3), (iv) at the 30th minute following cardiopulmonary bypass (T4) and (v) at the 8th hour following the operation (T5). Results: Group 1 patients had been discharged from hospital and 7 of them died (Group 2). In T1, a statistically significant difference (two folds) was detected between the two groups in terms of GSTP1 values. Although GSTP1 values of both groups decreased during cardiopulmanary bypass period (T2, T3), a statistically significant difference was found between the two groups (p=0.001). GSTP1 values of the study groups in T4 and T5 were measured to be higher than the values recorded in T1, T2 and T3 (P0.001). GSTP1 values of the Group 2 were also detected to increase by two folds in T4. Comparison of creatinine values produced no statistically significant difference between the two groups in the period from T1 to T4. Mean creatinin level of Group 2 was observed to considerably increase in T5 and a statistically significant difference was observed between the creatining levels of the two groups (P0.001). Conclusion: GSTP1 isoenzyme may be used as an early prognostic marker following a pediatric cardiac surgery with CPB.

• 出版日期2016