Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappa B activation

作者：Kanzawa Noriyuki; Nishigaki Kazuo^*; Hayashi Takaya; Ishii Yuichi; Furukawa Souichi; Niiro Ayako; Yasui Fumihiko; Kohara Michinori; Morita Kouichi; Matsushima Kouji; Lee Mai Quynh; Masuda Takao; Kannagi Mari

来源：FEBS LETTERS, 2006, 580(30): 6807-6812.

DOI：10.1016/j.febslet.2006.11.046

• SARS
• ARDS
• inflammation
• NF-kappa B
• transcription
• 1L-8

Severe acute respiratory syndrome (SARS) is characterized by rapidly progressing respiratory failure resembling acute/adult respiratory distress syndrome (ARDS) associated with uncontrolled inflammatory responses. Here, we demonstrated that, among five accessory proteins of SARS coronavirus (SARS-CoV) tested, 3a/X1 and 7a/X4 were capable of activating nuclear factor kappa B (NF-kappa B) and c-Jun N-terminal kinase (JNK), and significantly enhanced interleukin 8 (IL-8) promoter activity. Furthermore, 3a/X1 and 7a/X4 expression in A549 cells enhanced production of inflammatory chemokines that were known to be up-regulated in SARS-CoV infection. Our results suggest potential involvement of 3a/X1 and 7a/X4 proteins in the pathological inflammatory responses in SARS.

• 出版日期2006-12-22
• 单位河北医科大学