Association between polymorphisms in IL27 gene and renal cell carcinoma

作者：Pu, Yan; Chen, Peng; Zhou, Bin; Zhang, Peng; Wang, Yanyun; Song, Yaping; Zhang, Lin^*

来源：Biomarkers, 2015, 20(3): 202-205.

DOI：10.3109/1354750X.2015.1062555

• Cytokine
• genetic susceptibility
• IL27
• polymorphisms
• renal cell carcinoma

Context: Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis. @@@ Objective: To investigate whether polymorphisms in IL27 contribute to renal cell carcinoma (RCC) risk. @@@ Materials and methods: These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). @@@ Results: Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109: p = 0.006, OR = 1.364, 95% CI = 1.095-1.700; rs17855750: p = 0.001, OR = 1.768, 95% CI = 1.245-2.511). @@@ Conclusion: The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.

• 出版日期2015
• 单位四川大学