Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study

作者：Hermanns M Iris^*; Grossmann Vera; Spronk Henri M H; Schulz Andreas; Juenger Claus; Laubert Reh Dagmar; Mazur Johanna; Gori Tommaso; Zeller Tanja; Pfeiffer Norbert; Beutel Manfred; Blankenberg Stefan; Muenzel Thomas; Lackner Karl J; ten Cate Hoek Arina J; ten Cate Hugo; Wild Philipp S

来源：International Journal of Cardiology, 2015, 187: 166-174.

DOI：10.1016/j.ijcard.2015.03.330

• Venous thrombosis
• Arterial thrombosis
• Epidemiological studies
• FVIII:c reference values

Background: Elevated levels of FVIII:c are associated with risk for both venous and arterial thromboembolism. However, no population-based study on the sex-specific distribution and reference ranges of plasma FVIII: c and its cardiovascular determinants is available.
Methods: FVIII:c was analyzed in a randomly selected sample of 2533 males and 2440 females from the Gutenberg Health Study in Germany. Multivariable regression analyses for FVIII:c were performed under adjustment for genetic determinants, cardiovascular risk factors and cardiovascular disease.
Results and conclusions: Females (126.6% (95% CI: 125.2/128)) showed higher FVIII:c levels than males (121.2% (119.8/122.7)). FVIII:c levels increased with age in both sexes (beta per decade: 5.67% (4.22/7.13) male, 6.15% (4.72/7.57) female; p < 0.001). Sex-specific reference limits and categories indicating the grade of deviation from the reference were calculated, and nomograms for FVIII: c were created. FVIII: c was approximately 25% higher in individuals with non-O blood type. Adjusted for sex and age, ABO-blood group accounted for 18.3% of FVIII:c variation. In multivariable analysis, FVIII:c was notably positively associated with diabetes mellitus, obesity, hypertension and dyslipidemia and negatively with current smoking. In a fully adjusted multivariable model, the strongest associations observed were of elevated FVIII:c with diabetes and peripheral artery disease in both sexes and with obesity in males. Effects of SNPs in the vWF, STAB2 and SCARA5 gene were stronger in females than in males. The use of nomograms for valuation of FVIII:c might be useful to identify high-risk cohorts for thromboembolism. Additionally, the prospective evaluation of FVIII:c as a risk predictor becomes feasible.

• 出版日期2015-5-6
• 单位河北医科大学