科研之友
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摘要
A practical method is developed for the cleavage of catechol monomethyl ethers and o-carbonylphenyl methyl ethers using aluminum chloride and sodium iodide in acetonitrile. Acid scavengers such as 1,3-diisopropylcarbodiimide and CaO are used to prevent acid-labile functional groups from side-reactions. This method is efficient for the deprotection of various o-hydroxyphenyl methyl ethers such as acetovanillone, eugenol, guaiacol, vanillin, isovanillin and ortho-vanillin. The AlCl3-NaI system is less efficient than AlI3 for the cleavage of other typical aryl alkyl ethers without a neighboring hydroxyl or carbonyl group, or for the removal of bulkier alkyl groups from catechol monoalkyl ethers. This procedure represents a convenient approach for the preparation of catechols.
- 出版日期2018-9-21
- 单位荆楚理工学院
