An analysis of pancreas transplantation outcomes based on age groupings - an update of the UNOS database

作者：Siskind Eric^*; Maloney Caroline; Akerman Meredith; Alex Asha; Ashburn Sarah; Barlow Meade; Siskind Tamar; Bhaskaran Madhu; Ali Nicole; Basu Amit; Molmenti Ernesto; Ortiz Jorge

来源：Clinical Transplantation, 2014, 28(9): 990-994.

DOI：10.1111/ctr.12407

• age based outcomes
• graft survival
• pancreas transplantation
• rejection
• risk stratification

IntroductionPreviously, increasing age has been a part of the exclusion criteria used when determining eligibility for a pancreas transplant. However, the analysis of pancreas transplantation outcomes based on age groupings has largely been based on single-center reports.
MethodsA UNOS database review of all adult pancreas and kidney-pancreas transplants between 1996 and 2012 was performed. Patients were divided into groups based on age categories: 18-29 (n=1823), 30-39 (n=7624), 40-49 (n=7967), 50-59 (n=3160), and 60 (n=280). We compared survival outcomes and demographic variables between each age grouping.
ResultsOf the 20854 pancreas transplants, 3440 of the recipients were 50yr of age or above. Graft survival was consistently the greatest in adults 40-49yr of age. Graft survival was least in adults age 18-29 at one-, three-, and five-yr intervals. At 10- and 15-yr intervals, graft survival was the poorest in adults >60yr old. Patient survival and age were found to be inversely proportional; as the patient population's age increased, survival decreased.
ConclusionPancreas transplants performed in patients of increasing age demonstrate decreased patient and graft survival when compared to pancreas transplants in patients <50yr of age.

• 出版日期2014-9