A SIMPLE AND CONVENIENT HIGH YIELDING SYNTHESIS OF SUBSTITUTED ISOINDOLINES

作者：Smith Keith^*; El Hiti Gamal A; Hegazy Amany S; Fekri Ahmed

来源：Heterocycles, 2010, 80(2): 941-956.

DOI：10.3987/COM-09-S(S)61

• Cyclization
• Dehydration
• Heterocycle
• Substituted Benzyl-N,N-dimethylurea
• Synthesis

Trifluoroacetic anhydride-induced dehydration of substituted 2-(pivaloylaminomethyl)phenyl- and 2-(dimethylaminocarbonylmethyl)phenyl-methanols gives the corresponding isoindolines in excellent yields when there are aryl substituents at the methanol carbon atom.

• 出版日期2010-3-1