Association of positive well-being with reduced cardiac repolarization abnormalities in the First National Health and Nutrition Examination Survey

作者：Isakadze Nino; Soliman Elsayed Z; Vaccarino Viola; Whang William; Lampert Rachel; Bremner J Douglas; Shah Amit J^*

来源：International Journal of Cardiology, 2018, 265: 246-250.

DOI：10.1016/j.ijcard.2018.04.135

• Psychological well-being
• Cardiac repolarization
• Coronary heart disease

Background: The mechanisms by which psychological factors may influence possibly arrhythmia risk are not known. We hypothesized that psychological wellness, measured by the General Well-Being Schedule (GBWS), is associated with less repolarization heterogeneity as measured by T-axis. We also explored whether T-axis was a mediator in the relationship of GWBS with adverse cardiac outcomes.
Methods: We studied 5533 adults aged 25-74 years without a history of CVD from NHANES I (National Health and Nutrition Examination Survey) (1971-75). Frontal T-axis was obtained through 12-lead ECG and characterized as normal (15 degrees to 75 degrees), borderline (-15 degrees to 15 degrees or 75 degrees to 105 degrees) or abnormal (>105 degrees or <-15 degrees).
Results: The mean +/- SD age was 43.1 +/- 11.5 years and 55% were women. A 1-SD increase in GWBS score associated with a 23% reduced odds of abnormal T-axis (p < 0.001) and 11% lower hazard of composite CHD hospitalization and death (p = 0.02). When adjusting for sociodemographic factors, health behaviors, and CHD risk factors, the association was minimally changed and remained statistically significant. Additional adjustment for T-axis did not change the relationship with outcomes.
Conclusion: General well-being is independently associated with less abnormal frontal T-axis and CHD events in otherwise healthy individuals. Published by Elsevier B.V.

• 出版日期2018-8-15