Association of GSTP1 Ile105Val Polymorphism and Risk of Head and Neck Cancers: A Meta-Analysis of 28 Case-Control Studies

作者：Lang, Juntian; Song, Xicheng; Cheng, Jinwei; Zhao, Shuwei; Fan, Jingping^*

来源：PLos One, 2012, 7(11): e48132.

DOI：10.1371/journal.pone.0048132

• S-TRANSFERASE P1
• SQUAMOUS-CELL CARCINOMA
• GENETIC POLYMORPHISMS
• ORAL-CANCER
• METABOLIZING-ENZYMES
• DIOL EPOXIDES
• GLUTATHIONE
• GSTM1
• GSTT1
• TOBACCO

Background and Aims: The Glutathione S-transferase P1 (GSTP1) polymorphism have been considered a risk modifier for developing head and neck cancer (HNC) in many studies; however, the results of such studies are inconsistent. The aim of this study was to evaluate the possible association between the GSTP1 Ile105Val polymorphism and risk of HNC.
Method: We performed a search in the relevant electronic database and a meta-analysis based on 28 published case-control studies that included 6,404 cases and 6,523 controls. To take into account the possibility of heterogeneity across the studies, a Chi-square based I-2-statistic test was performed. Crude pooled odds ratios (ORs) with 95% confidence intervals (CIs) were assessed using both fixed-effects and random-effects models.
Results: The results of this meta-analysis showed that the GSTP1 Ile105Val polymorphism was not significantly associated with risk of HNC in the overall study population (pooled OR 1.00, 95% CI 0.92-1.09) or in subgroup analyses stratified by ethnicity, sample size, tumor site or publication year. Moreover, substantial evidence of heterogeneity among the studies was observed. Publication year was identified as the main cause of heterogeneity.
Conclusion: This meta-analysis does not support a significant association between the GSTP1 Ile105Val polymorphism and risk of HNC.

• 出版日期2012-11-7
• 单位青岛大学; 中国人民解放军第二军医大学; 天津市中医药研究院附属医院; 烟台毓璜顶医院