Fast BIA-amperometric determination of isoniazid in tablets

作者：Quintino Maria S M; Angnes Lucio^*

来源：Journal of Pharmaceutical and Biomedical Analysis, 2006, 42(3): 400-404.

DOI：10.1016/j.jpba.2006.04.006

• amperometry
• batch injection analysis
• glassy carbon electrode
• isoniazid
• pharmaceutical products

This paper proposes a new, fast and precise method to analyze isoniazid based on the electrochemical oxidation of the analyte at a glassy carbon electrode in 0.1 M NaOH. The quantification was performed utilizing amperometry associated with batch injection analysis (BIA) technique. Fast sequential analysis (60 determinations h(-1)) in an unusually wide linear dynamic range (from 2.5 x 10(-8) to 1.0 x 10(-3) M), with high sensitivity and low limits of detection (4.1 x 10(-9) M) and quantification (1.4 x 10(-8) M), was achieved. Such characteristics allied to a good repeatability of the current responses (relative standard deviation of 0.79% for 30 measurements), were explored for the specific determination of isoniazid in isoniazid-rifampin tablet.

• 出版日期2006-9-26